Von der Leyen said the Commission would provide Belgium with sweeping guarantees intended to clear the way for the loan, despite Belgian authorities warning that the plan carries potentially "disastrous" financial risks, the Euronews outlet reported.
The guarantees outlined on Wednesday include bilateral contributions from EU member states, legal safeguards against Russian retaliation and a new ban on returning sovereign Russian assets to Moscow, according to Euronews.
The Commission is seeking to overcome Belgium's resistance ahead of a key summit of EU leaders on December 18.
"We have created a very strong solidarity mechanism where in the very end the Union can intervene, because we want to make very sure to all our member states, but specifically also to Belgium, that we will share the burden in a fair way, as it is the European way," von der Leyen said, as cited by Euronews.
"We are sending a very strong signal to the Ukrainian people that we are in for the long haul. We can equip them with the means to defend themselves and, even more important, with the means to lead peace negotiations from a position of strength," she added.
Under the plan, the Commission would channel proceeds from immobilised Russian assets to Kyiv.
Most of those assets are held at Euroclear, a Brussels-based central securities depository.
Belgium has insisted on broad guarantees from fellow EU states to shield itself from possible Russian retaliation and financial losses.
Von der Leyen said last month that a reparations loan backed by frozen Russian assets would be the most effective way for Europe to meet Ukraine's financing needs.
"We give a loan to Ukraine – that Ukraine pays back if Russia pays reparations," she told the European Parliament at the time.
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Source: Euronews, IAR, PAP